A metabolite of carbamazepine and oxcarbazepine
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10,11-dihydro-10,11-dihydroxy Carbamazepine

Item No. 35436

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-10,11-dihydroxy-5H-dibenz[b,f]azepine-5-carboxamide
CAS Number
35079-97-1
Synonyms
  • 10,11-dihydro-10,11-dihydroxy CBZ
  • CBZ-diol
  • Dihydroxycarbazepine
  • Dihydroxycarbamazepine
Molecular Formula
C15H14N2O3
Formula Weight
270.3
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(N1C2=C(C(C(C3=C1C=CC=C3)O)O)C=CC=C2)N
InChi Code
InChI=1S/C15H14N2O3/c16-15(20)17-11-7-3-1-5-9(11)13(18)14(19)10-6-2-4-8-12(10)17/h1-8,13-14,18-19H,(H2,16,20)
InChi Key
PRGQOPPDPVELEG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    10,11-dihydro-10,11-dihydroxy Carbamazepine is a metabolite of the anticonvulsant carbamazepine and the antiepileptic prodrug oxcarbazepine (Item No. 17340).1 It is formed from carbamazepine via a carbamazepine 10,11-epoxide (Item No. 33908) intermediate by epoxide hydrolase and from oxcarbazepine via a 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467) intermediate.2,1 10,11-dihydro-10,11-dihydroxy Carbamazepine has been found in wastewater effluent.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Franceschi, L., and Furlanut, M. A simple method to monitor plasma concentrations of oxcarbazepine, carbamazepine, their main metabolites and lamotrigine in epileptic patients. Pharmacol. Res. 51(4), 297-302 (2005).

    2. Tybring, G., van Bahr, C., Bertilsson, L., et al. Metabolism of carbamazepine and its epoxide metabolite in human and rat liver in vitro. Drug. Metab. Dispos. 9(6), 561-564 (1981).

    3. Miao, X.-S., Yang, J.-J., and Metcalfe, C.D. Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant. Environ. Sci. Technol. 39(19), 7469-7475 (2005).