An internal standard for the quantification of oxcarbazepine
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Unlabeled Version(s)
17340Oxcarbazepine
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Oxcarbazepine-d4

Item No. 29995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-11-oxo-5H-dibenz[b,f]azepine-1,2,3,4-d4-5-carboxamide
CAS Number
1134188-71-8
Molecular Formula
C15H8D4N2O2
Formula Weight
256.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C1C2=C(C([2H])=C([2H])C([2H])=C2[2H])N(C(N)=O)C3=C(C=CC=C3)C1
InChi Code
InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)/i2D,4D,6D,8D
InChi Key
CTRLABGOLIVAIY-MNYIHESISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $262

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    Product Description

    Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine (Item No. 17340) by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Item No. 18467).1,2 It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM.2 Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; Item No. 18682) or picrotoxin (Item No. 20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ambrósio, A.F., Soares-Da-Silva, P., Carvalho, C.M., et al. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem. Res. 27(1-2), 121-130 (2002).

    2. McLean, M.J., Schmutz, M., Wamil, A.W., et al. Oxcarbazepine: Mechanisms of action. Epilepsia 35(Suppl. 3), S5-S9 (1994).