A potent and selective CECR2 inhibitor
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NVS-CECR2-1

Item No. 18316

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclopropyl-2-(propylsulfonyl)-6-[1-(2,2,6,6-tetramethyl-4-piperidinyl)-1H-indol-5-yl]-4-pyrimidinamine
CAS Number
1992047-61-6
Synonyms
  • NVS-1
Molecular Formula
C27H37N5O2S
Formula Weight
495.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.3 mg/ml
λmax
267 nm
SMILES
O=S(C1=NC(NC2CC2)=CC(C3=CC(C=CN4C5CC(C)(C)NC(C)(C)C5)=C4C=C3)=N1)(CCC)=O
InChi Code
InChI=1S/C27H37N5O2S/c1-6-13-35(33,34)25-29-22(15-24(30-25)28-20-8-9-20)18-7-10-23-19(14-18)11-12-32(23)21-16-26(2,3)31-27(4,5)17-21/h7,10-12,14-15,20-21,31H,6,8-9,13,16-17H2,1-5H3,(H,28,29,30)
InChi Key
XVECNLUKQDKOST-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $90

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    5 mg

    $241

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    10 mg

    $436

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    25 mg

    $869

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    Product Description

    NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 µM by Alpha screen, Kd = 0.80 µM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has no acute toxicity. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.