A melatonin analog
Related Products
Parent Compound(s)
20995Tryptamine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

N-acetyl Tryptamine

Item No. 18605

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(1H-indol-3-yl)ethyl]-acetamide
CAS Number
1016-47-3
Molecular Formula
C12H14N2O
Formula Weight
202.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
222, 282, 290 nm
SMILES
CC(NCCC1=CNC2=CC=CC=C21)=O
InChi Code
InChI=1S/C12H14N2O/c1-9(15)13-7-6-10-8-14-12-5-3-2-4-11(10)12/h2-5,8,14H,6-7H2,1H3,(H,13,15)
InChi Key
NVUGEQAEQJTCIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $54

    Add

    10 mg

    $96

    Add

    25 mg

    $158

    Add

    50 mg

    $290

    Add
    Product Description

    N-acetyl Tryptamine is a structural analog of melatonin (5-methoxy-N-acetyltryptamine; Item No. 14427) that binds the melatonin MT2 receptor (Ki = 41 nM).1 It acts as a melatonin receptor antagonist in frog skin and chicken retina and as a partial agonist in rabbit retina.2,3,4 N-acetyl Tryptamine is also a reaction product of assays for serotonin N-acetyltransferase, the penultimate enzyme in the melatonin biosynthetic pathway.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sugden, D., Pickering, H., Teh, M.T., et al. Melatonin receptor pharmacology: Toward subtype specificity. Biology of the Cell 89(8), 531-537 (1997).

    2. Dubocovich, M.L. Characterization of a retinal melatonin receptor. J. Pharmacol. Exp. Ther. 234(2), 395-401 (1985).

    3. Nonno, R., Pannacci, M., Lucini, V., et al. Ligand efficacy and potency at recombinant human MT2 melatonin receptors: Evidence for agonist activity of some mt1-antagonists. Brit. J. Pharmacol. 127(5), 1288-1294 (2016).

    4. Dubocovich, M.L., Masana, M.I., Iacob, S., et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn-Schmiedeberg's Arch. Pharmacol. 355(3), 365-375 (1997).

    5. DeAngelis, J., Gastel, J., Klein, D.C., et al. Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemisty 273(5), 3045-3050 (1998).