An inhibitor of CBX7
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UNC3866

Item No. 19237

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine, methyl ester
CAS Number
1872382-47-2
Molecular Formula
C43H66N6O8
Formula Weight
795.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mlEthanol: 16 mg/ml
λmax
240 nm
SMILES
CC(C)(C1=CC=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(OC)=O)CO)=O)CCCCN(CC)CC)=O)CC(C)C)=O)C)=O)CC2=CC=CC=C2)=O)C=C1)C
InChi Code
InChI=1S/C43H66N6O8/c1-10-49(11-2)24-16-15-19-33(39(53)48-36(27-50)42(56)57-9)45-41(55)34(25-28(3)4)46-37(51)29(5)44-40(54)35(26-30-17-13-12-14-18-30)47-38(52)31-20-22-32(23-21-31)43(6,7)8/h12-14,17-18,20-23,28-29,33-36,50H,10-11,15-16,19,24-27H2,1-9
InChi Key
UMRRDXVUROEIKJ-JCXBGQGISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $53

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    5 mg

    $168

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    10 mg

    $306

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    25 mg

    $636

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    Cayman Chemical
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    Product Description

    UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM).1 It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stuckey, J.I., Dickson, B.M., Cheng, N., et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat. Chem. Biol. 12(3), 180-187 (2016).