An FFAR1 (GPR40) antagonist
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DC260126

Item No. 19388

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-butylphenyl)-4-fluoro-benzenesulfonamide
CAS Number
346692-04-4
Molecular Formula
C16H18FNO2S
Formula Weight
307.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 100 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
FC1=CC=C(S(NC2=CC=C(CCCC)C=C2)(=O)=O)C=C1
InChi Code
InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3
InChi Key
CNGHPXKWPGIDSK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $51

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    10 mg

    $97

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    25 mg

    $164

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    50 mg

    $304

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    Cayman Chemical
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    Product Description

    DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively.1 At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, H., He, L.y., Gong, Z., et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem. Biophys. Res. Commun. 390(3), 557-563 (2009).

    2. Sun, T., Wang, T., Zhou, Y., et al. DC260126: A small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS One 8(6), (2013).