An RXR ligand
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LG 100754

Item No. 19647

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2E,4E,6Z-octatrienoic acid
CAS Number
180713-37-5
Synonyms
  • CD3159
  • LGD 100754
  • UVI2112
Molecular Formula
C26H36O3
Formula Weight
396.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
246, 256, 318 nm
SMILES
CC1(C)C2=C(C=C(/C(C)=C\C=C\C(C)=C\C(O)=O)C(OCCC)=C2)C(C)(C)CC1
InChi Code
InChI=1S/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11-
InChi Key
HNODNXQAYXJFMQ-LQUSFLDPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $502

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    LG 100754 is a ligand of retinoid X receptor (RXR) that modulates the activity of RXR dimers. It acts as an antagonist towards RXR homodimers but as an agonist of heterodimers consisting of RXR and retinoic acid receptor (RAR) or PPARs.1,2,3 LG 100754, at 1 µM, is a weak agonist of RXR-PPARγ but strongly enhances signaling through the heterodimer in response to PPARγ ligands, including rosiglitazone (Item No. 71740) and 15-deoxy-Δ12,14-prostaglandin J2 (Item No. 18570).4 Through this action, LG 100754 decreases glucose levels and relieves insulin resistance in mice.5,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hida, T., Tai, K., Tokuhara, N., et al. Existence of retinoic acid-receptor-independent retinoid X-receptor-dependent pathway in myeloid cell function. Jpn. J. Pharmacol. 85(1), 60-69 (2001).

    2. Lala, D.S., Mukherjee, R., Schulman, I.G., et al. Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature 383(6599), 450-453 (1996).

    3. Schulman, I.G., Li, C., Schwabe, J.W.R., et al. The phantom ligand effect: Allosteric control of transcription by the retinoid X receptor. Genes Dev. 11(3), 299-308 (1997).

    4. Forman, B.M. The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor gamma ligands. The Journal of Biological Chemisty 277(15), 12503-12506 (2002).

    5. Cesario, R.M., Klausing, K., Razzaghi, H., et al. The rexinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol. Endocrinol. 15(8), 1360-1369 (2001).