A selective TAF1 bromodomain 2 inhibitor
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CeMMEC1

Item No. 19956

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide
CAS Number
440662-09-9
Molecular Formula
C19H16N2O4
Formula Weight
336.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
212, 258, 296 nm
SMILES
O=C(C1=CN(C)C(C2=C1C=CC=C2)=O)NC3=CC4=C(C=C3)OCCO4
InChi Code
InChI=1S/C19H16N2O4/c1-21-11-15(13-4-2-3-5-14(13)19(21)23)18(22)20-12-6-7-16-17(10-12)25-9-8-24-16/h2-7,10-11H,8-9H2,1H3,(H,20,22)
InChi Key
PEOQAZBGLOADFJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $268

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    10 mg

    $469

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    Product Description

    CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (Kd = 1.8 µM; IC50 = 0.9 µM).1 It does not bind to either the first or second bromodomain of BRD4.1 This compound synergizes with (+)-JQ1 (Item No. 11187) to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sdelci, S., Lardeau, C.H., Tallant, C., et al. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nat. Chem. Biol. 12(7), 504-510 (2016).