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Mitragynine Pseudoindoxyl

Item No. 20033

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αE,6′S,7′S,8′aS)-6′-ethyl-1,2′,3,3′,6′,7′,8′,8′a-octahydro-4-methoxy-α-(methoxymethylene)-3-oxo-spiro[2H-indole-2,1′(5′H)-indolizine]-7′-acetic acid, methyl ester
Molecular Formula
C23H30N2O5
Formula Weight
414.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlChloroform: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=C2C(NC3([C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3)C2=O)=CC=C1
InChi Code
InChI=1S/C23H30N2O5/c1-5-14-12-25-10-9-23(19(25)11-15(14)16(13-28-2)22(27)30-4)21(26)20-17(24-23)7-6-8-18(20)29-3/h6-8,13-15,19,24H,5,9-12H2,1-4H3/b16-13+/t14-,15+,19+,23?/m1/s1
InChi Key
BAEJBRCYKACTAA-AIFWNKBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $490

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    Product Description

    Mitragynine pseudoindoxyl (Item No. 20033) is an analytical reference standard categorized as an opioid.1,2 Mitragynine pseudoindoxyl has analgesic activity in mice without inducing the development of opioid-induced hyperalgesia.2 It induces physical dependence in mice but reduces signs of withdrawal in morphine-dependent mice administered naloxone. This product is intended for research and forensic applications. For more information, please see Cayman's application note: Chromatographic Separation of 7-Hydroxy Mitragynine from Mitragynine Pseudoindoxyl.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Váradi, A., Marrone, G.F., Palmer, T.C., et al. Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2. 59(18), 8381-8397 (2016).

    2. Wilson, L.L., Chakraborty, S., Eans, S.O., et al. Kratom alkaloids, natural and semi-synthetic, show less physical dependence and ameliorate opioid withdrawal. Cell. Mol. Neurobiol. 41(5), 1131-1143 (2021).

    Product Citations

    Khan, S., Tyson, A.S., Ranjbar, M., et al. Structural snapshots capture nucleotide release at the μ-opioid receptor. Nature (2025).