A selective TAF1 bromodomain 2 inhibitor
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CeMMEC13

Item No. 20224

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide
CAS Number
1790895-25-8
Molecular Formula
C19H16N2O4
Formula Weight
336.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
211, 337 nm
SMILES
O=C(C1=CC(N(C)C2=C1C=CC=C2)=O)NC3=CC4=C(C=C3)OCCO4
InChi Code
InChI=1S/C19H16N2O4/c1-21-15-5-3-2-4-13(15)14(11-18(21)22)19(23)20-12-6-7-16-17(10-12)25-9-8-24-16/h2-7,10-11H,8-9H2,1H3,(H,20,23)
InChi Key
NXKBPGZQDHACPZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $268

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    10 mg

    $469

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    Cayman Chemical
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    Product Description

    CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).1 It does not bind to bromodomains of BRD4, BRD9, or CREBBP.1 CeMMEC13 synergizes with (+)-JQ1 (Item No. 11187) to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sdelci, S., Lardeau, C.H., Tallant, C., et al. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nat. Chem. Biol. 12(7), 504-510 (2016).