A secondary bile acid
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Hyodeoxycholic Acid

Item No. 20294

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3α,6α-dihydroxy-cholan-24-oic acid
CAS Number
83-49-8
Synonyms
  • HDCA
  • α-Hyodeoxycholic Acid
  • NSC 60672
Molecular Formula
C24H40O4
Formula Weight
392.6
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChi Key
DGABKXLVXPYZII-SIBKNCMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $63

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    10 g

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    25 g

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    50 g

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    Cayman Chemical
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    Product Description

    Hyodeoxycholic acid (HDCA) is a secondary bile acid.1 It is produced from lithocholic acid (Item No. 20253) by gut bacteria.1,2,3 Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.4 Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Einarsson, K. On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154. The Journal of Biological Chemisty 241(3), 534-539 (1966).

    2. Madsen, D., Beaver, M., Chang, L., et al. Analysis of bile acids in conventional and germfree rats. J. Lipid. Res. 17(2), 107-111 (1976).

    3. Sacquet, E., Parquet, M., Riottot, M., et al. Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man. J. Lipid. Res. 24(5), 604-613 (1983).

    4. Shih, D.M., Shaposhnik, Z., Meng, Y., et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 27(9), 3805-3817 (2013).

    5. Gnewuch, C., Liebisch, G., Langmann, T., et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J. Gastroenterol. 15(25), 3134-3141 (2009).