A P2Y12 receptor antagonist with antiplatelet activity
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Labeled Version(s)
33467Ticlopidine-d4 (hydrochloride)
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Ticlopidine (hydrochloride)

Item No. 20770

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, monohydrochloride
CAS Number
53885-35-1
Molecular Formula
C14H14ClNS • HCl
Formula Weight
300.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 0.1 mg/ml
SMILES
ClC1=C(CN2CCC(SC=C3)=C3C2)C=CC=C1.Cl
InChi Code
InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H
InChi Key
MTKNGOHFNXIVOS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $103

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    10 g

    $186

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    25 g

    $378

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    Product Description

    Ticlopidine is a thienopyridine P2Y12 receptor antagonist.1 It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).2 It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.3 Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.4 Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porto, I., Giubilato, S., De Maria, G.L., et al. Platelet P2Y12 receptor inhibition by thienopyridines: Status and future. Expert Opin. Investig. Drugs 18(9), 1317-1332 (2009).

    2. Bruno, J.J. The mechanisms of action of ticlopidine. Thromb. Res. Suppl. 4, 59-67 (1983).

    3. Sugidachi, A., Asai, F., Ogawa, T., et al. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br. J. Pharmacol. 129(7), 1439-1446 (2000).

    4. Ma, L., Elliott, S.N., Cirino, G., et al. Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release. Proc. Natl. Acad. Sci. USA 98(11), 6470-6475 (2001).