An internal standard for the quantification of ticlopidine
Related Products
Unlabeled Version(s)
20770Ticlopidine (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ticlopidine-d4 (hydrochloride)

Item No. 33467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(2-chlorophenyl-d4)methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, monohydrochloride
CAS Number
2932627-17-1
Molecular Formula
C14H10ClD4NS • HCl
Formula Weight
304.3
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
ClC(C([2H])=C([2H])C([2H])=C1[2H])=C1CN2CC3=C(SC=C3)CC2.Cl
InChi Code
InChI=1S/C14H14ClNS.ClH/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14;/h1-4,6,8H,5,7,9-10H2;1H/i1D,2D,3D,4D;
InChi Key
MTKNGOHFNXIVOS-FOMJDCLLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $141

    Add

    5 mg

    $559

    Add
    Product Description

    Ticlopidine-d4 is intended for use as an internal standard for the quantification of ticlopidine (Item No. 20770) by GC- or LC-MS. Ticlopidine is a thienopyridine P2Y12 receptor antagonist.1 It inhibits aggregation of human platelets induced by collagen, arachidonic acid (Item No. 90010), and ADP (Item No. 16778; IC50s = 75, 600, and 1,300 μM, respectively).2 It also inhibits ADP-induced aggregation of rat platelets and decreases thrombus weight in vivo in a rat model of arterio-venous shunt thrombosis when administered at a dose of 100 mg/kg.3 Ticlopidine (300 mg/kg) inhibits healing of acetic acid-induced gastric ulcers in rats.4 Formulations containing ticlopidine have been used in the prevention of thrombotic stroke.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porto, I., Giubilato, S., De Maria, G.L., et al. Platelet P2Y12 receptor inhibition by thienopyridines: Status and future. Expert Opin. Investig. Drugs 18(9), 1317-1332 (2009).

    2. Bruno, J.J. The mechanisms of action of ticlopidine. Thromb. Res. Suppl. 4, 59-67 (1983).

    3. Sugidachi, A., Asai, F., Ogawa, T., et al. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br. J. Pharmacol. 129(7), 1439-1446 (2000).

    4. Ma, L., Elliott, S.N., Cirino, G., et al. Platelets modulate gastric ulcer healing: Role of endostatin and vascular endothelial growth factor release. Proc. Natl. Acad. Sci. USA 98(11), 6470-6475 (2001).