A medium-chain saturated fatty acid
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Decanoic Acid (sodium salt)

Item No. 20838

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
decanoic acid, monosodium salt
CAS Number
1002-62-6
Synonyms
  • C10:0
  • Capric Acid
  • Decylic Acid
  • FA 10:0
Molecular Formula
C10H19O2 • Na
Formula Weight
194.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[O-]C(CCCCCCCCC)=O.[Na+]
InChi Code
InChI=1S/C10H20O2.Na/c1-2-3-4-5-6-7-8-9-10(11)12;/h2-9H2,1H3,(H,11,12);/q;+1/p-1
InChi Key
FIWQZURFGYXCEO-UHFFFAOYSA-M
Side Chain Carbon Sum
10:0
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    25 g

    $63

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    50 g

    $103

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    100 g

    $169

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    Product Description

    Decanoic acid is a medium-chain saturated fatty acid. It is a non-competitive antagonist at AMPA receptors that selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2 and GluA3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1 and GluA2 subunits (IC50 = 1.16 mM).1 It inhibits epileptiform activity induced by pentylenetetrazole (Item No. 18682) or low magnesium in rat hippocampal slices. Decanoic acid (1 mM) induces contractions in isolated guinea pig duodenum, an effect that can be blocked by the muscarinic acetylcholine receptor antagonist hyoscine, voltage-gated sodium channel inhibitor tetrodotoxin (Item Nos. 14964 | 14963), or M2 muscarinic acetylcholine receptor antagonist hexamethonium (Item No. 25505).2 It increases the escape threshold in an orofacial mechanical stimulation test in rats when administered at a topical dose of 30% in ointment form, indicating analgesic activity.3 This effect can be blocked by the muscarinic acetylcholine receptor antagonist methoctramine (Item No. 24317). Plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, P., Augustin, K., Boddum, K., et al. Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain 139(Pt 2), 431-443 (2016).

    2. Gwynne, R.M., Thomas, E.A., Goh, S.M., et al. Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum. J. Physiol. 556(Pt 2), 557-569 (2004).

    3. Noguchi, Y., Matsuzawa, N., Akama, Y., et al. Dietary constituent, decanoic acid suppresses the excitability of nociceptive trigeminal neuronal activity associated with hypoalgesia via muscarinic M2 receptor signaling. Mol. Pain 13, 1-11 (2017).

    4. Crotti, S., Agnoletto, E., Cancemi, G., et al. Altered plasma levels of decanoic acid in colorectal cancer as a new diagnostic biomarker. Anal. Bioanal. Chem. 408(23), 6321-6328 (2016).