A β2-adrenergic receptor antagonist
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Todralazine (hydrochloride)

Item No. 20893

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1-phthalazinyl)-hydrazinecarboxylic acid, ethyl ester, monohydrochloride
CAS Number
3778-76-5
Synonyms
  • Apirachol
  • Binazine
  • Ecarazine
Molecular Formula
C11H12N4O2 • HCl
Formula Weight
268.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): slightly
λmax
210, 303, 315 nm
SMILES
O=C(OCC)NNC1=C2C(C=CC=C2)=CN=N1.Cl
InChi Code
InChI=1S/C11H12N4O2.ClH/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10;/h3-7H,2H2,1H3,(H,13,14)(H,15,16);1H
InChi Key
OMCOKCNIYWULQH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $94

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    500 mg

    $174

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    1 g

    $329

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    Product Description

    Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity.1,2 Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation.2 It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Falase, A.O., and Salako, L.A. β-Adrenoceptor blockers in the treatment of hypertension. Afr. J. Med. Med. Sci. 8(1-2), 13-18 (1979).

    2. Dimri, M., Joshi, J., Chakrabarti, R., et al. Todralazine protects zebrafish from lethal effects of ionizing radiation: Role of hematopoietic cell expansion. Zebrafish 12(1), 33-47 (2015).

    3. Murata, K., Hamada, M., Sugimoto, K., et al. A novel mechanism for drug-induced liver failure: Inhibition of histone acetylation by hydralazine derivatives. J. Hepatol. 46(2), 322-329 (2007).