A β2-adrenergic receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Todralazine (hydrochloride)

Item No. 20893

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1-phthalazinyl)-hydrazinecarboxylic acid, ethyl ester, monohydrochloride
CAS Number
3778-76-5
Synonyms
  • Apirachol
  • Binazine
  • Ecarazine
Molecular Formula
C11H12N4O2 • HCl
Formula Weight
268.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): slightly
λmax
210, 303, 315 nm
SMILES
O=C(OCC)NNC1=C2C(C=CC=C2)=CN=N1.Cl
InChi Code
InChI=1S/C11H12N4O2.ClH/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10;/h3-7H,2H2,1H3,(H,13,14)(H,15,16);1H
InChi Key
OMCOKCNIYWULQH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 mg

    $94

    Add

    500 mg

    $174

    Add

    1 g

    $329

    Add
    Product Description

    Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity.1,2 Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation.2 It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Falase, A.O., and Salako, L.A. β-Adrenoceptor blockers in the treatment of hypertension. Afr. J. Med. Med. Sci. 8(1-2), 13-18 (1979).

    2. Dimri, M., Joshi, J., Chakrabarti, R., et al. Todralazine protects zebrafish from lethal effects of ionizing radiation: Role of hematopoietic cell expansion. Zebrafish 12(1), 33-47 (2015).

    3. Murata, K., Hamada, M., Sugimoto, K., et al. A novel mechanism for drug-induced liver failure: Inhibition of histone acetylation by hydralazine derivatives. J. Hepatol. 46(2), 322-329 (2007).