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Paraxanthine

Item № 21068
CAS № 611-59-6
Purity ≥98%
product image
                (CAS 611-59-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     10 mg $35.00 0.00
     25 mg $66.00 0.00
     50 mg $96.00 0.00
     100 mg $140.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • 1,7-Dimethylxanthine
  • NSC 400018

Paraxanthine is an inhibitor of phosphodiesterase 9 (PDE9) and an antagonist of adenosine receptors A1 and A2 (Kis = 35 and 22 μM, respectively in equine forebrain tissues).1,2 It is the main metabolite of caffeine (Item No. 14118) in humans, making up 80% of the three dimethylxanthine metabolites produced by caffeine demethylation.1,3 Paraxanthine increases locomotor activity and counteracts adenosine receptor agonist-induced motor depression in rats not habituated to caffeine.1 At a dose of 30 mg/kg, paraxanthine induces a significant increase in striatal cGMP and extracellular striatal dopamine concentrations in vivo. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.3

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Technical Information
Formal Name
3,7-dihydro-1,7-dimethyl-1H-purine-2,6-dione
CAS Number
611-59-6
Synonyms
  • 1,7-Dimethylxanthine
  • NSC 400018
Molecular Formula
C7H8N4O2
Formula Weight
180.2
Purity
≥98%
Formulation
A crystalline solid
λmax
269 nm
SMILES
O=C(C(N(C)C=N1)=C1N2)N(C)C2=O
InChI Code
InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13)
InChI Key
QUNWUDVFRNGTCO-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Orrú, M., Guitart, X., Karcz-Kubicha, M., et al. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans Neuropharmacology 67, 476-484 (2013).

2. Chou, C.-C., and Vickroy, T.W. Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues Am. J. Vet. Res. 64(2), 216-224 (2003).

3. Okuro, M., Fujiki, N., Kotorii, N., et al. Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice Sleep 33(7), 930-942 (2010).

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