An internal standard for the quantification of AHU377
Related Products
Unlabeled Version(s)
36260AHU377 21473AHU377 (calcium salt)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AHU377-d4

Item No. 25264

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,γS)-γ-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid, α-ethyl ester
CAS Number
1884269-07-1
Synonyms
  • Sacubitril-d4
Molecular Formula
C24H25D4NO5
Formula Weight
415.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A film
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleDMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
C[C@@H](C(OCC)=O)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1
InChi Code
InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1/i13D2,14D2
InChi Key
PYNXFZCZUAOOQC-JCZLLWNUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $69

    Add

    1 mg

    $120

    Add

    5 mg

    $525

    Add
    Product Description

    AHU377-d4 is intended for use as an internal standard for the quantification of AHU377 (Item Nos. 36230 | 21473) by GC- or LC-MS. AHU377 is an ethyl ester prodrug form of the neprilysin inhibitor LBQ657 (Item No. 19829).1 It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used in the treatment of mild to moderate hypertension and chronic heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ksander, G.M., Ghai, R.D., deJesus, R., et al. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J. Med. Chem. 38(10), 1689-1700 (1995).