A monoterpene with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(+)-Limonene

Item No. 21719

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-4R-(1-methylethenyl)-cyclohexene
CAS Number
5989-27-5
Synonyms
  • (+)-Dipentene
  • D-Limonene
  • (R)-(+)-Limonene
Molecular Formula
C10H16
Formula Weight
136.2
Purity
≥98%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
λmax
203 nm
SMILES
CC1=CC[C@H](C(C)=C)CC1
InChi Code
InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3/t10-/m0/s1
InChi Key
XMGQYMWWDOXHJM-JTQLQIEISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $42

    Add

    5 mg

    $143

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    (+)-Limonene is a monoterpene that has been found in citrus oils and Cannabis and has diverse biological activities.1,2,3,4 It is active against S. aureus, B. cereus, E. faecalis, E. coli, P. aeruginosa, K. pneumoniae, M. catarrhalis, and C. neoformans (MICs = 3-27 mg/ml).1 In a human BGC-823 gastric cancer nude mouse orthotopic transplantation model, (+)-limonene inhibits tumor growth by 47.6% and reduces the number of metastases in the liver, peritoneum, and other organs when administered by gastric perfusion at a dose of 15 ml/kg.5 Dietary administration of (+)-limonene (5 and 10% in chow) reverses doxorubicin-induced decreases in glutathione (GSH) levels in rat kidney.3 (+)-Limonene is toxic to cockroaches and house flies (LD50s = 700 and 90 µg/insect, respectively).6 Formulations containing (+)-limonene have been used as flavoring and fragrance agents, in the treatment of gallstones, heartburn, and gastroesophageal reflux disorder, as well as in the control of insects and algae.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Vuuren, S.F., and Viljoen, A.M. Antimicrobial activity of limonene enantiomers and 1,8-cineole alone and in combination. Flavor and Frag. J. 22(6), 540-544 (2007).

    2. Sun, J. D-Limonene: Safety and clinical applications. Altern. Med. Rev. 12(3), 259-264 (2007).

    3. Rehman, M.U., Tahir, M., Khan, A.Q., et al. D-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats. Exp. Biol. Med. (Maywood) 239(4), 465-476 (2014).

    4.  Handbook of Cannabis therapeutics from bench to bedside. (2010).

    5. Lu, X.-G., Zhan, L.-B., Feng, B.-A., et al. Inhibition of growth and metastasis of human gastric cancer implanted in nude mice by d-limonene. World J. Gastroenterol. 10(14), 2140-2144 (2004).

    6. Karr, J.R., and Coats, J.R. Insecticidal properties of d-limonene. J. Pesticide Sci. 12(2), 287-290 (1988).