A monoterpene with diverse biological activities
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γ-Terpinene

Item No. 23722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-4-(1-methylethyl)-1,4-cyclohexadiene
CAS Number
99-85-4
Synonyms
  • NSC 21448
Molecular Formula
C10H16
Formula Weight
136.2
Purity
≥95%
Formulation (Request formulation change)
A neat oil
SMILES
CC1=CCC(C(C)C)=CC1
InChi Code
InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,7-8H,5-6H2,1-3H3
InChi Key
YKFLAYDHMOASIY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $63

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    250 mg

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    500 mg

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    Product Description

    γ-Terpinene is a monoterpene that has been found in various plants, including C. sativa, with diverse biological activities.1,2,3,4,5,6 It scavenges 2,2'-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS+) free radicals (IC50s = 2.8 and 30 mM, respectively) and reduces hemolysis induced by AAPH (Item No. 82235) in isolated human erythrocytes.2 γ-Terpinene reduces the growth of T. evansi in a concentration-dependent manner.3 It increases membrane permeability and decreases growth of X. oryzae bacteria.4 In vivo, γ-terpinene (100 mg/kg) reduces Triton WR1339-induced increases in serum cholesterol and triglyceride levels in rats.5 It reduces paw edema induced by histamine, bradykinin (Item No. 37408), carrageenan, and prostaglandin E2 (PGE2; Item No. 14010) in mice.6 It also inhibits fluid extravasation in a mouse model of acetic acid microvascular permeability and reduces neutrophil migration in lung in a mouse model of acute lung injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hazekamp, A., Tejkalová, K., and Papadimitriou, S. Cannabis: From cultivar to chemovar II—A metabolomics approach to Cannabis classification. Cannabis Cannabinoid Res. 1(1), 202-215 (2016).

    2. Li, G.-X., and Liu, Z.-Q. Unusual antioxidant behavior of α- and γ-terpinene in protecting methyl linoleate, DNA, and erythrocyte. J. Agric. Food Chem. 57(9), 3943-3948 (2009).

    3. Baldissera, M.D., Grando, T.H., Souza, C.F., et al. In vitro and in vivo action of terpinen-4-ol, γ-terpinene, and α-terpinene against Trypanosoma evansi. Exp. Parasitol. 162, 43-48 (2016).

    4. Yoshitomi, K., Taniguchi, S., Tanaka, K., et al. Rice terpene synthase 24 (OsTPS24) encodes a jasmonate-responsive monoterpene synthase that produces an antibacterial γ-terpinene against rice pathogen. J. Plant Physiol. 191(1), 120-126 (2016).

    5. Takahashi, Y., Inaba, N., Kuwahara, S., et al. Effects of γ-terpinene on lipid concentrations in serum using Triton WR1339-treated rats. Biosci. Biotechnol. Biochem. 67(11), 2448-2450 (2003).

    6. Ramalho, T.R., Oliveira, M.T., Lima, A.L., et al. Gamma-terpinene modulates acute inflammatory response in mice. Planta. Med. 81(14), 1248-1254 (2015).