A monoterpene with diverse biological activities
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α-Phellandrene

Item No. 23179

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-5-(1-methylethyl)-1,3-cyclohexadiene
CAS Number
99-83-2
Synonyms
  • p-Mentha-1,5-diene
  • (±)-α-Phellandrene
Molecular Formula
C10H16
Formula Weight
136.2
Purity
≥80%
Formulation (Request formulation change)
An oil
Solubility(Learn about Variance in Solubility)
Benzene: SolubleChloroform: Soluble
SMILES
CC1=CCC(C(C)C)C=C1
InChi Code
InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4-6,8,10H,7H2,1-3H3
InChi Key
OGLDWXZKYODSOB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $36

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    5 g

    $128

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    Product Description

    α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities.1 In vivo, α-phellandrene (50, 100, and 200 mg/kg, p.o.) reduces carrageenan-induced neutrophil accumulation and leukocyte rolling and adhesion as well as inhibits production of the pro-inflammatory cytokines TNF-α and IL-6 in a rat model of air pouch inflammation.2 It decreases spleen weight and increases macrophage phagocytosis and natural killer (NK) cell cytotoxic activity in a murine WEHI-3 leukemia model.3 α-Phellandrene has antinociceptive effects in mouse models of pain, reducing acetic acid-induced writhing, paw licking in the capsaicin test, and glutamate-induced licking and biting behavior, as well as increases the paw withdrawal threshold following carrageenan-induced inflammation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giese, M.W., Lewis, M.A., Giese, L., et al. Development and Validation of a Reliable and Robust Method for the Analysis of Cannabinoids and Terpenes in Cannabis. J. AOAC Int. 98(6), 1503-1522 (2015).

    2. Siqueira, H.D., Neto, B.S., Sousa, D.P., et al. α-Phellandrene, a cyclic monoterpene, attenuates inflammatory response through neutrophil migration inhibition and mast cell degranulation. Life Sci. 160, 27-33 (2016).

    3. Lin, J.-J., Lu, K.-W., Ma, Y.-S., et al. Alpha-phellandrene, a natural active monoterpene, influences a murine WEHI-3 leukemia model in vivo by enhancing macrophague phagocytosis and natural killer cell activity. In Vivo 28(4), 583-588 (2014).

    4. Lima, D.F., Brandão, M.S., Moura, J.B., et al. Antinociceptive activity of the monoterpene α-phellandrene in rodents: Possible mechanisms of action. J. Pharm. Pharmacol. 64(2), 283-292 (2012).