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Hydrocodone (bitartrate)

Item No. 22166

Restricted Product (Schedule II)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Dihydrocodeinone
  • (–)-Hydrocodone
Technical Information
Formal Name
4,5α-epoxy-3-methoxy-17-methyl-morphinan-6-one, (2R,3R)-2,3-dihydroxybutanedioate
CAS Number
143-71-5
Molecular Formula
C18H21NO3 • C4H6O6
Formula Weight
449.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CN1[C@H]2[C@@]3([H])[C@]4(CC1)[C@](OC5=C4C(C2)=CC=C5OC)([H])C(CC3)=O.OC([C@H](O)[C@@H](O)C(O)=O)=O
InChi Code
InChI=1S/C18H21NO3.C4H6O6/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10/h3,6,11-12,17H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-,12+,17-,18-;1-,2-/m01/s1
InChi Key
OJHZNMVJJKMFGX-BWCYBWMMSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Hydrocodone (bitartrate) (Item No. 22166) is an analytical reference standard categorized as an opioid.1,2 It is a metabolite of codeine (Item Nos. ISO60140 | 15459 | 26514).3 Like other opioid analgesics, hydrocodone is commonly abused.4 Hydrocodone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Trescot, A.M., Datta, S., Lee, M., et al. Opioid pharmacology. Pain Physician 11(2 Suppl.), S133-S153 (2008).

    2. Codd, E.E., Shank, R.P., Schupsky, J.J., et al. Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: Structural determinants and role in antinociception. J. Pharmacol. Exp. Ther. 274(3), 1263-1270 (1995).

    3. Oyler, J.M., Cone, E.J., Joseph, R.E., Jr., et al. Identification of hydrocodone in human urine following controlled codeine administration. J. Anal. Toxicol. 24(7), 530-535 (2000).

    4. Atluri, S.A., Sudarshan, G., and Manchikanti, L. Assessment of the trends in medical use and misuse of opioid analgesics from 2004 to 2011. Pain Physician 17(2), E119-E128 (2014).