A metabolite of lansoprazole
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Lansoprazole sulfone

Item No. 22569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole
CAS Number
131926-99-3
Synonyms
  • AG-1813
Molecular Formula
C16H14F3N3O3S
Formula Weight
385.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
281 nm
SMILES
CC1=C(CS(C2=NC(C=CC=C3)=C3N2)(=O)=O)N=CC=C1OCC(F)(F)F
InChi Code
InChI=1S/C16H14F3N3O3S/c1-10-13(20-7-6-14(10)25-9-16(17,18)19)8-26(23,24)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
InChi Key
TVMJMCGRSSSSDJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Lansoprazole sulfone is a phase I metabolite of lansoprazole (Item Nos. 13627 | 21967 | 18235).1 Lansoprazole is a proton pump inhibitor that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.2 Lansoprazole is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form lansoprazole sulfone.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meyer, U.A. Interaction of proton pump inhibitors with cytochromes P450: Consequences for drug interactions. Yale J. Biol. Med. 69(3), 203-209 (1996).

    2. Schubert, M.L. Pharmacotherapy for acid/peptic disorders. Yale J. Biol. Med. 69(2), 197-201 (1996).