A glycine-conjugated form of hyocholic acid
Related Products
Isomer(s)
20276Glycocholic Acid
Labeled Version(s)
27034Glycohyocholic Acid-d4
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Glycohyocholic Acid

Item No. 22670

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3α,5β,6α,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine
CAS Number
32747-08-3
Synonyms
  • GHCA
  • Glycine Hyocholate
  • Glycohyocholate
Molecular Formula
C26H43NO6
Formula Weight
465.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
202 nm
SMILES
O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](O)[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCC(O)=O)=O)([H])C1
InChi Code
InChI=1S/C26H43NO6/c1-14(4-7-20(29)27-13-21(30)31)16-5-6-17-22-18(9-11-25(16,17)2)26(3)10-8-15(28)12-19(26)23(32)24(22)33/h14-19,22-24,28,32-33H,4-13H2,1-3H3,(H,27,29)(H,30,31)/t14-,15-,16-,17+,18+,19+,22+,23-,24+,25-,26-/m1/s1
InChi Key
ZQYUKJFJPJDMMR-ZDWCHQGWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Glycohyocholic acid (GHCA) is a glycine-conjugated form of the primary bile acid hyocholic acid (Item No. 20293).1 GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.2 Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, L., Milburn, M.V., Ryals, J.A., et al. Plasma metabolomic profiles enhance precision medicine for volunteers of normal health. Proc. Natl. Acad. Sci. USA 112(35), E4901-E4910 (2015).

    2. Fitian, A.I., Nelson, D.R., Liu, C., et al. Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. Liver Int. 34(9), 1428-1444 (2014).

    3. Yu, H., Ni, Y., Bao, Y., et al. Chenodeoxycholic acid as a potential prognostic marker for Roux-en-Y gastric bypass in Chinese obese patients. J. Clin. Endocrinol. Metab. 100(11), 4222-4230 (2015).