An internal standard for the quantification of glycohyocholic acid
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Unlabeled Version(s)
22670Glycohyocholic Acid
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Glycohyocholic Acid-d4

Item No. 27034

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3α,5β,6α,7α)-3,6,7-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine
Synonyms
  • GHCA-d4
  • Glycine Hyocholate-d4
  • Glycohyocholate-d4
Molecular Formula
C26H39D4NO6
Formula Weight
469.7
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
O[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@]([C@@H](O)[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCC(O)=O)=O)([H])C1([2H])[2H]
InChi Code
InChI=1S/C26H43NO6/c1-14(4-7-20(29)27-13-21(30)31)16-5-6-17-22-18(9-11-25(16,17)2)26(3)10-8-15(28)12-19(26)23(32)24(22)33/h14-19,22-24,28,32-33H,4-13H2,1-3H3,(H,27,29)(H,30,31)/t14-,15-,16-,17+,18+,19+,22+,23-,24+,25-,26-/m1/s1/i8D2,12D2
InChi Key
ZQYUKJFJPJDMMR-FWCDZUIRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $268

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Glycohyocholic Acid-d4 (GHCA-d4) is intended for use as an internal standard for the quantification of GHCA (Item No. 22670) by GC- or LC-MS. GHCA is a glycine-conjugated form of the primary bile acid hyocholic acid (Item No. 20293).1 GHCA is upregulated 6.6-fold in the serum of patients with cirrhosis induced by hepatitis C virus (HCV) compared to healthy controls.2 Plasma levels of GHCA increase in patients who are no longer diabetic following gastric bypass surgery.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, L., Milburn, M.V., Ryals, J.A., et al. Plasma metabolomic profiles enhance precision medicine for volunteers of normal health. Proc. Natl. Acad. Sci. USA 112(35), E4901-E4910 (2015).

    2. Fitian, A.I., Nelson, D.R., Liu, C., et al. Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS-MS. Liver Int. 34(9), 1428-1444 (2014).

    3. Yu, H., Ni, Y., Bao, Y., et al. Chenodeoxycholic acid as a potential prognostic marker for Roux-en-Y gastric bypass in Chinese obese patients. J. Clin. Endocrinol. Metab. 100(11), 4222-4230 (2015).