An inhibitor of CK1α, CK1δ, and CK1ε
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Epiblastin A

Item No. 22758

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(3-chlorophenyl)-2,4,7-pteridinetriamine
CAS Number
16470-02-3
Molecular Formula
C12H10ClN7
Formula Weight
287.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
NC1=NC2=NC(N)=NC(N)=C2N=C1C3=CC(Cl)=CC=C3
InChi Code
InChI=1S/C12H10ClN7/c13-6-3-1-2-5(4-6)7-9(14)18-11-8(17-7)10(15)19-12(16)20-11/h1-4H,(H6,14,15,16,18,19,20)
InChi Key
ZWNKKZSRANLVEW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $86

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    Product Description

    Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively).1 It is selective for CK1α, CK1δ, and CK1ε at concentrations below 10 μM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s = 24-45 μM). Epiblastan A reduces immunoprecipitation of CK1α, CK1δ, and CK1ε from HCT116 cell lysates in a concentration-dependent manner. It induces reprogramming of mouse epiblast stem cells (mEpiSCs) into embryonic stem cells (ESCs) 8-fold more efficiently than triamterene (Item Nos. 21242 | 22486).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ursu, A., Illich, D.J., Takemoto, Y., et al. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of Casein Kinase 1. Cell Chem. Biol. 23(4), 494-507 (2016).