A β-adrenergic receptor antagonist
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(±)-Propranolol (hydrochloride)

Item No. 23349

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, monohydrochloride
CAS Number
318-98-9
Synonyms
  • ICI 45520
  • NSC 91523
Molecular Formula
C16H21NO2 • HCl
Formula Weight
295.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
215 nm
SMILES
OC(CNC(C)C)COC1=C2C(C=CC=C2)=CC=C1.Cl
InChi Code
InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
InChi Key
ZMRUPTIKESYGQW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $69

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    10 g

    $102

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    25 g

    $132

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    50 g

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    Product Description

    (±)-Propranolol is a β-adrenergic receptor (β-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human β1-, β2-, and β3-ARs, respectively).1 It reduces mean blood pressure, resting heart rate, and contractility and increases AV conduction time in dogs.2 (±)-Propranolol restores normal sinus rhythm in dogs with ouabain-induced arrhythmias (ED50 = 3.8 mg/kg).3 It also acts as a non-specific serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats.4 Formulations containing (±)-propranolol have been used for the treatment of hypertension, angina pectoris, and cardiac ischemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).

    2. Fitzgerald, J.D., and O'Donnell, S.R. A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogs. Brit. J. Pharmacol. 45(2), 207-217 (1972).

    3. Basil, B., Jordan, R., Loveless, A.H., et al. A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practolol. Br. J. Pharmacol. 50(3), 323-333 (1974).

    4. Costain, D.W., and Green, A.R. β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. Br. J. Pharmacol. 64(2), 193-200 (1978).