An ATAD2 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BAY-850

Item No. 23422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-2-[(cis-4-aminocyclohexyl)amino]-1-[(4-cyanophenyl)methyl]ethyl]-2-chloro-4-methoxy-5-[5-[[[(1R)-1-(4-methylphenyl)ethyl]amino]methyl]-2-furanyl]-benzamide
CAS Number
2099142-76-2
Molecular Formula
C38H44ClN5O3
Formula Weight
654.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=C(C2=CC=C(CN[C@H](C)C3=CC=C(C)C=C3)O2)C=C(C(N[C@@H](CN[C@H]4CC[C@@H](N)CC4)CC5=CC=C(C#N)C=C5)=O)C(Cl)=C1
InChi Code
InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12-29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H,44,45)/t25-,29-,30+,31-/m1/s1
InChi Key
BSISGUIVBKDTQO-QIKYYPRYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $33

    Add

    5 mg

    $132

    Add

    10 mg

    $198

    Add
    Product Description

    BAY-850 is an inhibitor of the ATPase family AAA domain-containing protein 2 (ATAD2; IC50 = 22 nM in a time-resolved FRET assay using a tetra-acetylated histone H4 peptide).1 It is selective for ATAD2 over a panel of 32 bromodomain family proteins, including ATAD2B, a panel of 354 kinases, and a panel of 25 G protein-coupled receptors (GPCRs) at 1 µM. BAY-850 induces dimerization of ATAD2 in a concentration-dependent manner in a cell-free assay and inhibits the ATAD2-chromatin interaction in MCF-7 breast cancer cells in a fluorescence recovery after photobleaching (FRAP) assay. It induces apoptosis and cell cycle arrest in, and inhibits proliferation, invasion, and migration of, PA-1 and SKOV3 ovarian cancer cells when used at a concentration of 5 µM.2 BAY-850 (20 mg/kg) reduces tumor volume and the percentage of lung metastases in a SKOV3 mouse xenograft model. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fernández-Montalván, A.E., Berger, M., Kuropka, B., et al. Isoform-selective ATAD2 chemical probe with novel chemical structure and unusual mode of action. ACS Chem. Biol. 12(11), 2730-2736 (2017).

    2. Guruvaiah, P., Chava, S., Sun, C.W., et al. ATAD2 is a driver and a therapeutic target in ovarian cancer that functions by upregulating CENPE. Cell Death Dis. 14(7), 456 (2023).