A bombesin-like neuropeptide
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Neuromedin C (trifluoroacetate salt)

Item No. 24706

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-L-histidine-5-14-bombesin
Synonyms
  • GRP(18-27)
  • NMC
Molecular Formula
C50H73N17O11S • XCF3COOH
Formula Weight
1120.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CN[H])=O)=O)CC1=CN=CN1)=O)CC2=CNC3=C2C=CC=C3)=O)C)=O)=O)=O)CC4=CN=CN4)=O)=O)CCSC)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C50H73N17O11S.C2HF3O2/c1-25(2)13-34(46(74)63-33(43(53)71)11-12-79-6)64-47(75)36(15-29-20-54-23-58-29)62-41(70)22-57-50(78)42(26(3)4)67-44(72)27(5)60-45(73)35(14-28-19-56-32-10-8-7-9-31(28)32)65-48(76)37(16-30-21-55-24-59-30)66-49(77)38(17-39(52)68)61-40(69)18-51;3-2(4,5)1(6)7/h7-10,19-21,23-27,33-38,42,56H,11-18,22,51H2,1-6H3,(H2,52,68)(H2,53,71)(H,54,58)(H,55,59)(H,57,78)(H,60,73)(H,61,69)(H,62,70)(H,63,74)(H,64,75)(H,65,76)(H,66,77)(H,67,72);(H,6,7)/t27-,33-,34-,35-,36-,37-,38-,42-;/m0./s1
InChi Key
YTDVZQVYMKGASO-PQMUPELQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $112

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    Product Description

    Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin (Item No. 24457), somatostatin, and amylase in rats.1,2 Neuromedin C is a truncated form of gastrin-releasing peptide (GRP; Item Nos. 24415 | 24455) corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin (Item No. 24151) binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate (Item No. 16880).2 Neuromedin C induces scratching and mast cell degranulation in mice when administered intradermally at doses ranging from 1 to 300 nmol/site, which is inhibited by the BB2 bombesin receptor agonist RC-3095 and reduced in mast cell-deficient mice.3 Neuromedin C (3.2 nmol/kg, i.p.) reduces rat glucose consumption by approximately 50% for up to one hour.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Madaus, S., Schusdziarra, V., Seufferlein, T., et al. Effect of gastrin-releasing peptide (GRP1-27), neuromedin-C (GRP18-27), and neuromedin-B on gastrin and somatostatin secretion from the rat stomach. Z. Gastroenterol. 27(9), 449-454 (1989).

    2. Sekar, M.C., Uemura, N., Coy, D.H., et al. Bombesin, neuromedin B and neuromedin C interact with a common rat pancreatic phosphoinositide-coupled receptor, but are differentially regulated by guanine nucleotides. Biochem J. 280(Pt. 1), 163-169 (1991).

    3. Andoh, T., Kuwazono, T., Lee, J.-B., et al. Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice. Peptides 32(10), 2098-2103 (2011).

    4. Ladenheim, E.E., Taylor, J.E., Coy, D.H., et al. Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist. Eur. J. Pharmacol. 271(1), R7-R9 (1994).