A triterpenoid saponin with diverse biological activities
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Saikosaponin A

Item No. 25026

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α,16β)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
CAS Number
20736-09-8
Molecular Formula
C42H68O13
Formula Weight
781.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:9): 0.1 mg/ml
SMILES
O[C@H]([C@H]1O)[C@H](O)[C@@H](CO)O[C@@]1([H])O[C@H]([C@H]2O)[C@@H](O)[C@@H](C)O[C@@]2([H])O[C@H]3CC[C@@]4(C)[C@](CC[C@]5(C)[C@]4([H])C=C[C@@]6(OC7)[C@@]5(C)C[C@H](O)[C@]87[C@@]6([H])CC(C)(C)CC8)([H])[C@@]3(CO)C
InChi Code
InChI=1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26+,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1
InChi Key
KYWSCMDFVARMPN-MSSMMRRTSA-N
Origin
Plant/Bupleuri radix
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    25 mg

    $534

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    Product Description

    Saikosaponin A is a triterpenoid saponin with diverse biological activities, including anti-inflammatory, antiallergic, anticonvulsive, antiproliferative, and antiviral properties.1,2,3,4 Saikosaponin A reduces expression of TNF-α, IL-6, and IL-1β in primary mouse macrophages stimulated by LPS.5 It also increases the survival rate in mice with LPS-induced lethal endotoxemia in a dose-dependent manner.5 Saikosaponin A (20 mg/kg, i.v., per day) reduces weight loss, brain edema, blood-brain barrier disruption, and IL-6 and TNF-α protein levels in the ipsilateral cortex compared to control animals in a rat model of traumatic brain injury.6 It also reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo when administered at a dose of 8 mg/kg.2 It reduces the duration and frequency of epileptiform activity in rat hippocampal CA1 neurons in a dose-dependent manner in a 4-aminopyridine (4-AP; Item No. 18511) seizure model.3 Saikosaponin A (20 µM) decreases viability in six human colon carcinoma (HCC), H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines.7 It also prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo when used at a dose of 2 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, X.-H., Li, T., Fong, C.M., et al. Saponins from Chinese medicines as anticancer agents. Molecules 21(10), pii:E1326 (2016).

    2. Han, N.R., Kim, H.M., and Jeong, H.J. Inactivation of cystein-aspartic acid protease (caspase)-1 by saikosaponin A. Biol. Pharm. Bull. 34(6), 817-823 (2011).

    3. Xie, W., Yu, Y.H., Du, Y.P., et al. Saikosaponin a enhances transient inactivating potassium current in rat hippocampal CA1 neurons. Evid. Based Complement. Altnernat. Med. 2013:413092, (2013).

    4. Chen, J., Duan, M., Zhao, Y., et al. Saikosaponin A inhibits influenza A virus replication and lung immunopathology. Oncotarget 6(40), 42541-42556 (2015).

    5. Wei, Z., Wang, J., Shi, M., et al. Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages. Oncotarget 7(31), 48995-49007 (2016).

    6. Mao, X., Miao, G., Tao, X., et al. Saikosaponin a protects TBI rats after controlled cortical impact and the underlying mechanism. Am. J. Transl. Res. 8(1), 133-141 (2016).

    7. Kang, S.J., Lee, Y.J., Kang, S.G., et al. Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cells. Oncotarget 8(59), 100433-100448 (2017).