A triterpenoid saponin with diverse biological activities
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Saikosaponin B2

Item No. 39936

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4α,16α)-16,23,28-trihydroxyoleana-11,13(18)-dien-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
CAS Number
58316-41-9
Molecular Formula
C42H68O13
Formula Weight
781.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
C[C@@]([C@@]1(CC[C@@]2([H])[C@]3(C)CO)C)(C[C@H]4O)C(C=C[C@]1([H])[C@]2(CC[C@@H]3O[C@H](O[C@@H]5C)[C@@H]([C@H]([C@H]5O)O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]([C@H]6O)CO)O)C)=C(CC7(C)C)[C@@]4(CC7)CO
InChi Code
InChI=1S/C42H68O13/c1-21-29(47)34(55-35-32(50)31(49)30(48)24(18-43)53-35)33(51)36(52-21)54-28-11-12-38(4)25(39(28,5)19-44)10-13-40(6)26(38)9-8-22-23-16-37(2,3)14-15-42(23,20-45)27(46)17-41(22,40)7/h8-9,21,24-36,43-51H,10-20H2,1-7H3/t21-,24-,25-,26-,27-,28+,29+,30-,31+,32-,33-,34+,35+,36+,38+,39+,40-,41-,42-/m1/s1
InChi Key
WRYJYFCCMSVEPQ-ORAXXRKOSA-N
Origin
Plant/Bupleurum falcatum
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $43

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    5 mg

    $108

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    10 mg

    $172

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    25 mg

    $376

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    Product Description

    Saikosaponin B2 is a triterpenoid saponin that has been found in B. chinensis and has diverse biological activities.1,2,3 It is an antagonist of transient receptor potential ankyrin 1 (TRPA1) and inhibits calcium flux induced by polygodial (Item No. 14979) or allyl isothiocyanate in HEK293 cells expressing human TRPA1 when used at concentrations ranging from 0.5 to 1.5 µM.1 Saikosaponin B2 inhibits hepatitis C virus (HCV) viral entry into, but not replication in, Huh7.5 cells (EC50 = 16.13 µM) with a 50% cytotoxic concentration (CC50) value of 740.4 µM.2 It protects SH-SY5Y cells from hydrogen peroxide-induced cell death when used at a concentration of 50 µg/ml.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, G., Choi, J., Nam, Y.-J., et al. Identification and characterization of saikosaponins as antagonists of transient receptor potential A1 channel. Phytother Res. 34(4), 788-795 (2020).

    2. Lin, L.T., Chung, C.Y., Hsu, W.C., et al. Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. J. Hepatol. 62(3), 541-548 (2015).

    3. Zhang, Y., Liu, F., Zhang, X., et al. Recognition and identification of active components from Radix Bupleuri using human neuroblastoma SH-SY5Y cells. Biomed. Chromatogr. 30(3), 440-446 (2015).