A sesquiterpene alcohol
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(+)-Cedrol

Item No. 25769

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,3aS,6R,7R,8aS)-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol
CAS Number
77-53-2
Synonyms
  • α-Cedrol
Molecular Formula
C15H26O
Formula Weight
222.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Heated
SMILES
CC([C@]1([H])[C@](C)(O)CC2)(C)[C@@]3([H])[C@@]2(C1)[C@H](C)CC3
InChi Code
InChI=1S/C15H26O/c1-10-5-6-11-13(2,3)12-9-15(10,11)8-7-14(12,4)16/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m1/s1
InChi Key
SVURIXNDRWRAFU-OGMFBOKVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $75

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    250 mg

    $168

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    Product Description

    (+)-Cedrol is a sesquiterpene alcohol that has been used in Cannabis testing and has diverse biological activities.1 It inhibits the growth of L. sulphureus, G. trabeum, L. betulina, and T. versicolor wood decay fungi when used at a concentration of 100 μg/ml.2 (+)-Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively).3 In vivo, (+)-cedrol (200 mg/kg) prevents hair follicle dystrophy and reduces hair loss in a mouse model of alopecia induced by cyclophosphamide (Item No. 13849).4 (+)-Cedrol-loaded nanostructured lipid particles reduce peritoneal mast cell degranulation, a component of the type I anaphylactic response, induced by compound 48/80 (Item No. 22173) in mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fischedick, J.T. Identification of terpenoid chemotypes among high (–)-trans-Δ9-tetrahydrocannabinol-producing Cannabis sativa L. cultivars. Cannabis Cannabinoid Res. 2(1), 34-47 (2017).

    2. Cheng, S.S., Chung, M.J., Lin, C.Y., et al. Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents. J. Agric. Food Chem. 60(1), 124-128 (2012).

    3. Jeong, H.U., Kwon, S.S., Kong, T.Y., et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J. Toxicol. Environ. Health A 77(22-24), 1522-1532 (2014).

    4. Chen, S.S., Zhang, Y., Lu, Q.L., et al. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice. Environ. Toxicol. Pharmacol. 46, 270-276 (2016).

    5. Chakraborty, S., Kar, N., Kumari, L., et al. Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice. Int. J. Nanomedicine 12, 4849-4868 (2017).