A flavonoid with diverse biological activities
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Troxerutin

Item No. 27220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one
CAS Number
7085-55-4
Synonyms
  • Trihydroxyethylrutin
  • Vitamin P4
Molecular Formula
C33H42O19
Formula Weight
742.7
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
257, 352 nm
SMILES
O=C1C2=C(O)C=C(OCCO)C=C2OC(C3=CC=C(OCCO)C(OCCO)=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4
InChi Code
InChI=1S/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/m0/s1
InChi Key
IYVFNTXFRYQLRP-VVSTWUKXSA-N
Origin
Plant/Flos Sophorae Immaturus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $61

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    25 g

    $95

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    100 g

    $336

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.1,2,3 It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).1 Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).2 Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fan, S.-h., Zhang, Z.-f., Zheng, Y.-l., et al. Troxerutin protects the mouse kidney from D-galactose-caused injury through anti-inflammation and anti-oxidation. Int. Immunopharmacol. 9(1), 91-96 (2009).

    2. Yu, Y., and Zheng, G. Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. Mol. Med. Rep. 15(6), 3473-3478 (2017).

    3. Baluchnejadmojarad, T., Jamali-Raeufy, N., Zabihnejad, S., et al. Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson’s disease: Possible involvement of PI3K/ERβ signaling. Eur. J. Pharmacol. 801, 72-78 (2017).