FPR2 (C-Term) Polyclonal Antibody

Formyl peptide receptor 2 (FPR2) is a G protein-coupled receptor (GPCR).¹ It is encoded by FPR2 and is expressed in lung, kidney, spleen, placenta, macrophages, peripheral blood leukocytes, synovial fibroblasts, T cells, and intestinal epithelial cells. FPR2 is coupled to the G_i/o transduction pathway and is activated by various ligands including formyl peptides from bacteria and mitochondria, endogenous and aspirin-triggered resolvin D1, lipoxin A₄ (Item No. 90410), annexin A1 (Item No. 19881), amyloid-β (1-42) (Aβ42; Item No. 20574), and prion protein (106-126) (Item No. 24556), among others.^1,2,3 Activation of FPR2 by formylated bacterial peptides increases monocyte chemotaxis and neutrophil recruitment in vitro, and fpr2^-/- mice exhibit increased bacterial load and reduced neutrophil infiltration in response to L. monocytogenes infection.⁴ FPR2 activation by resolvin D1 (Item No. 10012554) reduces production of pro-inflammatory cytokines and reduces inflammatory pain in various murine models.⁵ Expression of FPR2 is increased in mononuclear phagocytes in postmortem brain tissue from patients with Alzheimer's disease and transient interaction of Aβ42 with FPR2 promotes receptor complex internalization and cytosolic deposition of Aβ42 in macrophages.⁶ Cayman's FPR2 (C-Term) Polyclonal Antibody can be used for Western blot and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminus of FPR2 from human samples.

WARNING This product is not for human or veterinary use.

1. Bäck, M., Powell, W.S., Dahlén, S.E., et al. Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7. Br. J. Pharmacol. 171(15), 3551-3574 (2014).

2. Cattaneo, F., Parisi, M., and Ammendola, R. Distinct signaling cascades elicited by different formyl peptide receptor 2 (FPR2) agonists. Int. J. Mol. Sci. 14(4), 7193-7230 (2013).

3. He, H.-Q., and Ye, R.-D. The formyl peptide receptors: Diversity of ligands and mechanism for recognition. Molecules 22(3), E455 (2017).

4. Alessi, M.C., Cenac, N., Si-Tahar, M., et al. FPR2: A novel promising target for the treatment of influenza. Front. Microbiol. 8:1719, (2017).

5. Zhang, L.-Y., Liu, Z.-H., Zhu, Q., et al. Resolvin D2 relieving radicular pain is associated with regulation of inflammatory mediators, Akt/GSK-3β signal pathway and GPR18. Neurochem. Res. 43(12), 2384-2392 (2018).

6. Iribarren, P., Zhou, Y., Hu, J., et al. Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease. Immunol. Res. 31(3), 165-176 (2005).