A histamine H3 receptor antagonist and histamine H1 receptor agonist
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Labeled Version(s)
35559Betahistine-d3 (hydrochloride)
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Betahistine (hydrochloride)

Item No. 27602

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-2-pyridineethanamine, dihydrochloride
CAS Number
5579-84-0
Molecular Formula
C8H12N2 • 2HCl
Formula Weight
209.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMSO: 2mg/mLEthanol: 2.5mg/mLPBS (pH 7.2): 5mg/mL
λmax
261, 268 nm
SMILES
CNCCC1=CC=CC=N1.Cl.Cl
InChi Code
InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H
InChi Key
XVDFMHARQUBJRE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $77

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    10 g

    $103

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Betahistine is a histamine H3 receptor antagonist and histamine H1 receptor agonist.1 In vivo, betahistine dilates pre-capillary arterioles and increases blood flow to the stria vascularis in guinea pigs.2,3 Betahistine (8 mg/kg) reduces weight gain and increased feeding behavior induced by olanzapine (Item No. 11937) in female rats.4 Formulations containing betahistine have been used in the treatment of balance disorders and vertigo symptoms associated with Meniere's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Timmerman, H. Histamine agonists and antagonists. Acta Otolaryngol. Suppl. 479, 5-11 (1991).

    2. Bertlich, M., Ihler, F., Sharaf, K., et al. Betahistine metabolites, aminoethylpyridine, and hydroxyethylpyridine increase cochlear blood flow in guinea pigs in vivo. Int. J. Audiol. 53(10), 753-759 (2014).

    3. Bertlich, M., Ihler, F., Weiss, B.G., et al. Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear model. Life Sci. 187, 17-21 (2017).

    4. Lian, J., Huang, X.-F., Pai, N., et al. Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications. Pharmacol. Res. 106, 51-63 (2016).