A secoiridoid glycoside with diverse biological activities
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Swertiamarin

Item No. 27634

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4aR,5R,6S)-5-ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one
CAS Number
17388-39-5
Molecular Formula
C16H22O10
Formula Weight
374.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMSO: 10mg/mLEthanol: 3mg/mLPBS (pH 7.2): 10mg/mL
λmax
238 nm
SMILES
O=C1OCC[C@]2(O)C1=CO[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2C=C
InChi Code
InChI=1S/C16H22O10/c1-2-7-14(24-6-8-13(21)23-4-3-16(7,8)22)26-15-12(20)11(19)10(18)9(5-17)25-15/h2,6-7,9-12,14-15,17-20,22H,1,3-5H2/t7-,9+,10+,11-,12+,14-,15-,16+/m0/s1
InChi Key
HEYZWPRKKUGDCR-QBXMEVCASA-N
Origin
Plant/Swertia chirayita
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $134

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    25 mg

    $266

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    50 mg

    $498

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    100 mg

    $795

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Swertiamarin is an orally bioavailable secoiridoid glycoside that has been found in E. axillare and has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties.1,2,3,4,5 It scavenges ABTS (Item No. 27317) radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively).1 Swertiamarin (50 μg/ml) inhibits nitric oxide (NO) production in IL-1β-stimulated fibroblast-like synoviocytes (FLSs) isolated from rat hindpaw.2 Swertiamarin (25 μg/ml) inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells.4 It decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced nonalcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg per day.5 Swertiamarin (50 mg/kg per day) also decreases fasting blood glucose and serum cholesterol levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vaijanathappa, J., and Badami, S. Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare. Planta Med. 75(1), 12-17 (2009).

    2. Saravanan, S., Islam, V.I., Thirugnanasambantham, K., et al. Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes. Inflamm. Res. 63(6), 451-462 (2014).

    3. Sonawane, R.D., Vishwakarma, S.L., Lakshmi, S., et al. Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats. Mol. Cell Biochem. 340(1-2), 1-6 (2010).

    4. Patel, T.P., Rawal, K., Soni, S., et al. Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. Biomed. Pharmacother. 83, 785-791 (2016).

    5. Yang, Y., Li, J., Wei, C., et al. Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. Phytomedicine 59, 152782 (2019).