A phenothiazine antipsychotic
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Acepromazine (maleate)

Item No. 27821

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-ethanone, mono-2Z-butenedioate
CAS Number
3598-37-6
Synonyms
  • ACE
  • Acetylpromazine
  • NSC 264522
Molecular Formula
C19H22N2OS • C4H4O4
Formula Weight
442.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1mg/mLDMSO: 3mg/mLEthanol: 2mg/mLPBS (pH 7.2): 2mg/mL
λmax
242, 278 nm
SMILES
CN(C)CCCN1C2=C(C=CC(C(C)=O)=C2)SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
FQRHOOHLUYHMGG-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $103

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    50 mg

    $253

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    100 mg

    $303

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    250 mg

    $378

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    Product Description

    Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine (Item No. 16129), and a dopamine receptor antagonist.1 It also binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine (Item No. 23829; IC50 = 840 nM).2 Acepromazine inhibits morphine-induced vomiting in dogs.3 It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively).4 Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Monteiro, E.R., Teixeira Neto, F.J., Castro, V.B., et al. Effects of acepromazine on the cardiovascular actions of dopamine in anesthetized dogs. Vet. Anaesth. Analg. 34(5), 312-321 (2007).

    2. Fjalland, B., Christensen, A.V., and Hyttel, J. Peripheral and central muscarinic receptor affinity of psychotropic drugs. Naunyn. Schmiedebergs. Arch. Pharmacol. 301(1), 5-9 (1977).

    3. Koh, R.B., Isaza, N., Xie, H., et al. Effects of maropitant, acepromazine, and electroacupuncture on vomiting associated with administration of morphine in dogs. J. Am. Vet. Med. Assoc. 244(7), 820-829 (2014).

    4. J., A. Pharmacological specificity of conditioned avoidance response inhibition in rats: Inhibition by neuroleptics and correlation to dopamine receptor blockade. Acta. Pharmacol. Toxicol. (Copenh). 51(4), 321-329 (1982).