A major metabolite of dasatinib
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Parent Compound(s)
11498Dasatinib
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Dasatinib N-oxide

Item No. 27845

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-4-oxido-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
CAS Number
910297-52-8
Molecular Formula
C22H26ClN7O3S
Formula Weight
504.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
218, 230, 321 nm
SMILES
OCC[N+](CC1)([O-])CCN1C2=CC(NC3=NC=C(C(NC4=C(Cl)C=CC=C4C)=O)S3)=NC(C)=N2
InChi Code
InChI=1S/C22H26ClN7O3S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(34-17)27-18-12-19(26-15(2)25-18)29-6-8-30(33,9-7-29)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChi Key
UEFNEEZCTQCRAW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dasatinib N-oxide is a major metabolite of the Abl and Src kinase inhibitor dasatinib (Item No. 11498).1 It is also a potential impurity in commercial preparations of dasatinib.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Christopher, L.J., Cui, D., Li, W., et al. Biotransformation of [14C]dasatinib: In vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys. Drug Metab. Dispos. 36(7), 1341-1356 (2008).

    2. Plachká, K., Švec, F., and Nováková, L. Ultra-high performance supercritical fluid chromatography in impurity control: Searching for generic screening approach. Anal. Chim. Acta 1039, 149-161 (2018).