An inhibitor of the NSD2-H3K36me2 nucleosome interaction
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UNC6934

Item No. 28814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
CAS Number
2561494-77-5
Molecular Formula
C24H21N5O4
Formula Weight
443.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N1)COC2=C1C=CC(C(N(C3CC3)CC4=CC=C(C(NC5=NC=NC=C5)=O)C=C4)=O)=C2
InChi Code
InChI=1S/C24H21N5O4/c30-22-13-33-20-11-17(5-8-19(20)27-22)24(32)29(18-6-7-18)12-15-1-3-16(4-2-15)23(31)28-21-9-10-25-14-26-21/h1-5,8-11,14,18H,6-7,12-13H2,(H,27,30)(H,25,26,28,31)
InChi Key
KOZGEDUWAQFVAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $124

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    25 mg

    $277

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    Cayman Chemical
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    Product Description

    UNC6934 is an inhibitor of the protein-protein interaction between histone-lysine N-methyltransferase NSD2 and dimethylated lysine 36 histone 3 (H3K36me2) nucleosomes (IC50 = 104 nM).1 It binds to NSD2 (Kd = 92 nM). UNC6934 also inhibits the serotonin transporter (SERT) and μ-opioid receptor (Kis = 1.4 and 8 µM, respectively). It induces NSD2 nucleolus accumulation in U2OS cells when used at a concentration of 5 µM. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dilworth, D., Hanley, R.P., Ferreira de Freitas, R., et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat. Chem. Biol. 18(1), 56-63 (2022).