A prenylated flavonoid with diverse biological activities
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Isomer(s)
35861Pomiferin
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Morusin

Item No. 28857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-buten-1-yl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one
CAS Number
62596-29-6
Synonyms
  • Mulberrochromene
  • NSC 649220
Molecular Formula
C25H24O6
Formula Weight
420.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/ml
λmax
271 nm
SMILES
OC1=CC=C(C(OC2=C3C(O)=CC4=C2C=CC(C)(C)O4)=C(C/C=C(C)/C)C3=O)C(O)=C1
InChi Code
InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3
InChi Key
XFFOMNJIDRDDLQ-UHFFFAOYSA-N
Origin
Plant/Cortex mori
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $178

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    50 mg

    $734

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    Cayman Chemical
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    Product Description

    Morusin is a prenylated flavonoid that has been found in M. alba and has diverse biological activities, including enzyme inhibitory, anti-inflammatory, and antiproliferative properties.1,2,3,4 It inhibits the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A7, and UGT1A8 (IC50s = 4.23, 0.98, and 3 μM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, CYP2C9, and CYP2E1 (IC50s = 2.13, 1.27, 3.18, and 9.28 μM, respectively).1 Morusin (4 μM) inhibits histamine and leukotriene C4 (LTC4) production induced by A23187 (Item No. 11016) and phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in mouse MC/9 mast cells.2 It also inhibits the growth of MCF-7, MDA‑MB‑231, and MDA‑MB‑453 breast cancer cells (IC50s = 13.53, 10.84, and 11.99 μM, respectively).3 Morusin (12.5 mg/kg per day) decreases colonic tissue damage, TGF-β1 levels, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shi, X., Yang, S., Zhang, G., et al. The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes. Xenobiotica 46(5), 467-476 (2016).

    2. Jin, S.E., Ha, H., Shin, H.K., et al. Anti-allergic and anti-inflammatory effects of kuwanon G and morusin on MC/9 mast cells and HaCaT keratinocytes. Molecules 24(2), E265 (2019).

    3. Kang, S., Kim, E.O., Kim, S.H., et al. Morusin induces apoptosis by regulating expression of bax and survivin in human breast cancer cells. Oncol. Lett. 13(6), 4558-4562 (2017).

    4. Nagle, A., Wu, T., Kuhen, K., et al. Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents. J. Med. Chem. 55(9), 4244-4273 (2012).