A phenylpropanoid glycoside with diverse biological activities
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Forsythoside B

Item No. 29051

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)ethyl O-D-apio-β-D-furanosyl-(1→6)-O-[6-deoxy-α-L-mannopyranosyl-(1→3)]-β-D-glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
CAS Number
81525-13-5
Molecular Formula
C34H44O19
Formula Weight
756.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
333 nm
SMILES
OC(C=C1)=C(O)C=C1CCO[C@@H]2O[C@H](CO[C@H]3[C@H](O)[C@](CO)(O)CO3)[C@@H](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@H]2O
InChi Code
InChI=1S/C34H44O19/c1-15-24(41)25(42)26(43)32(50-15)53-29-27(44)31(47-9-8-17-3-6-19(37)21(39)11-17)51-22(12-48-33-30(45)34(46,13-35)14-49-33)28(29)52-23(40)7-4-16-2-5-18(36)20(38)10-16/h2-7,10-11,15,22,24-33,35-39,41-46H,8-9,12-14H2,1H3/b7-4+/t15-,22+,24-,25+,26+,27+,28+,29+,30-,31+,32-,33+,34+/m0/s1
InChi Key
JMBINOWGIHWPJI-UNSOMVRXSA-N
Origin
Plant/Callicarpa kwangtungensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Forsythoside B is phenylpropanoid glycoside that has been found in M. alysson and has diverse biological activities.1,2,3,4,5 It scavenges PTIO (Item No. 14982), ABTS (Item No. 27317), O2-, and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell-free assays (IC50s = 125.5, 14, 262.6, and 8.7 μM, respectively).2 Forsythoside B (10-100 μg/ml) reduces hydrogen peroxide-induced cytotoxicity in bone marrow-derived mesenchymal stem cells (bmMSCs). It inhibits 2-aminoethoxydiphenyl borate-induced activation of transient receptor potential vanilloid 3 (TRPV3; IC50 = 6.7 μM in HEK293 cells expressing the human receptor) and reduces carvacrol-induced scratching behavior in mice.3 Forsythoside B (40 mg/kg) reduces serum levels of TNF-α, IL-6, IL-10, endotoxin, and triggering receptor expressed on myeloid cells 1 (TREM-1) and increases survival in a rat model of cecal ligation and puncture-induced sepsis.4 It also reduces infarct size and brain edema in a rat model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Çaliş, İ., Hosny, M., Khalifa, T., et al. Phenylpropanoid glycosides from Marrubium alysson. Phytochemistry 31(10), 3624-3626 (1992).

    2. Li, X., Xie, Y., Li, K., et al. Antioxidation and cytoprotection of acteoside and its derivatives: Comparison and mechanistic chemistry. Molecules 23(2), 498 (2018).

    3. Zhang, H., Sun, X., Qi, H., et al. Pharmacological inhibition of the temperature-sensitive and Ca2+-permeable transient receptor potential vanilloid TRPV3 channel by natural forsythoside B attenuates pruritus and cytotoxicity of kratinocytes. J. Pharmacol. Exp. Ther. 368(1), 21-31 (2018).

    4. Jiang, W.-L., Yong-Xu, Zhang, S.-P., et al. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Phytother. Res. 26(7), 981-987 (2012).

    5. Jiang, W.-L., Tian, J.-W., Fu, F.-h., et al. Neuroprotective efficacy and therapeutic window of Forsythoside B: In a rat model of cerebral ischemia and reperfusion injury. Eur. J. Pharmacol. 640(1-3), 75-81 (2010).