A polyhydroxy flavone with diverse biological activities
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Norwogonin

Item No. 29227

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7,8-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
CAS Number
4443-09-8
Synonyms
  • NSC 128304
  • 5,7,8-Trihydroxyflavone
Molecular Formula
C15H10O5
Formula Weight
270.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.1 mg/mlEthanol: 0.1 mg/ml
SMILES
O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC(O)=C31
InChi Code
InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H
InChi Key
ZFKKRRMUPBBYRS-UHFFFAOYSA-N
Origin
Plant/Scutellaria baicalensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

    $297

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    10 mg

    $525

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    Product Description

    Norwogonin is a polyhydroxy flavone that has been found in S. baicalensis and has diverse biological activities, including antioxidant, antiviral, and anticancer properties.1,2,3 It scavenges ABTS (Item No. 27317) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with IC50 values of 1.24 and 35.61 μg/ml, respectively, in cell-free assays.1 Norwogonin inhibits cytopathic effects induced by enterovirus 71 (EV71) in infected Vero cells (IC50 = 31.83 μg/ml).2 It reduces the viability of MDA-MB-231, BT-549, HCC70, and HCC1806 triple-negative breast cancer (TNBC) cells (IC50s = 32.24, 56.2, 39.05, and 37.3 μM, respectively) but not the non-tumorigenic cell lines MCF-10A and AG11132 (IC50s = >100 μM for both).3 Norwogonin induces cell cycle arrest at the G1 and G2/M phases and increases apoptosis in MDA-MB-231 cells in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sarian, M.N., Ahmed, Q.U., Mat So'ad, S.Z., et al. Antioxidant and antidiabetic effects of flavonoids: A structure-activity relationship based study. Biomed. Res. Int. 2017:8386065, (2017).

    2. Choi, H.J., Song, H.-H., Lee, J.-S., et al. Inhibitory effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71. Biomol. Ther. (Seoul) 24(5), 552-558 (2016).

    3. Abd El-Hafeez, A.A., Khalifa, H.O., Mahdy, E.A.M., et al. Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-κB, and STAT3. Pharmacol. Rep. 71(2), 289-298 (2019).