A flavonoid with diverse biological activities
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7,3',4'-Trihydroxyflavone

Item No. 29880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one
CAS Number
2150-11-0
Synonyms
  • 3’,4’,7-Trihydroxyflavone
  • 5-Deoxyluteolin
Molecular Formula
C15H10O5
Formula Weight
270.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/ml
λmax
238, 343 nm
SMILES
O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=C1C=CC(O)=C3
InChi Code
InChI=1S/C15H10O5/c16-9-2-3-10-12(18)7-14(20-15(10)6-9)8-1-4-11(17)13(19)5-8/h1-7,16-17,19H
InChi Key
PVFGJHYLIHMCQD-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

    $134

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    50 mg

    $228

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    100 mg

    $371

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    Product Description

    7,3’,4’-Trihydroxyflavone is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 µM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 µM).1 7,3’,4’-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 µM).2 It is active against M. tuberculosis (MIC = 50 µg/ml).3 It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, M.J., Chung, H.Y., Kang, S.S., et al. Antioxidant activity from the stem bark of Albizzia julibrissin. Arch. Pharm. Res. 26(6), 458-462 (2003).

    2. Selvam, C., Jachak, S.M., and Bhutani, K.K. Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. Phytother. Res. 18(7), 582-584 (2004).

    3. Chokchaisiri, R., Suaisom, C., Sriphota, S., et al. Bioactive flavonoids of the flowers of Butea monosperma. Chem. Pharm. Bull. (Tokyo) 57(4), 428-432 (2009).

    4. Kang, J.H., Lee, J., Moon, M., et al. 3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. Pharmazie 70(10), 661-667 (2015).