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Protonitazene (hydrochloride)

Item No. 29381

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Pronitazene
Technical Information
Formal Name
N,N-diethyl-5-nitro-2-[(4-propoxyphenyl)methyl]-1H-benzimidazole-1-ethanamine, monohydrochloride
CAS Number
119276-01-6
Molecular Formula
C23H30N4O3 • HCl
Formula Weight
447.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25mg/mLDMF:PBS (pH 7.2) (1:1): 0.5mg/mLDMSO: 20mg/mLEthanol: 10mg/mL
λmax
240, 302 nm
SMILES
CCN(CC)CCN1C(CC2=CC=C(OCCC)C=C2)=NC3=CC([N+]([O-])=O)=CC=C31.Cl
InChi Code
InChI=1S/C23H30N4O3.ClH/c1-4-15-30-20-10-7-18(8-11-20)16-23-24-21-17-19(27(28)29)9-12-22(21)26(23)14-13-25(5-2)6-3;/h7-12,17H,4-6,13-16H2,1-3H3;1H
InChi Key
HXFAZCCRNXARMH-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Protonitazene (hydrochloride) (Item No. 29381) is an analytical reference standard categorized as an opioid.1 Protonitazene has analgesic effects in mice.2 Protonitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).

    2. Ujváry, I., Christie, R., Evans-Brown, M., et al. DARK classics in chemical neuroscience: Etonitazene and related benzimidazoles. ACS Chem. Neurosci. 12(7), 1072-1092 (2021).

    Product Citations

    Truver, M.T., Roman, M., Gomonit, M.M., et al. Fatal intoxications with nitazenes: Postmortem findings, toxicology, and in vitro characterization at the μ-opioid receptor of six nitazene analogues. Arch. Toxicol. (2026).

    Kozell, L.B., Eshelman, A., J., Wolfrum, K.M., et al. Pharmacologic characterization of substituted nitazenes at μ, κ, and Δ opioid receptors suggests high potential for toxicity. J. Pharmacol. Exp. Ther. 389(2), 219-228 (2024).

    Tsai, M.-H.M., Chen, L., Baumann, M.H., et al. In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS Chem. Neurosci. 15(4), 854-867 (2024).

    Glatfelter, G.C., Vandeputte, M.M., Chen, L., et al. Alkoxy chain length governs the potency of 2-benzylbenzimidazole “nitazene” opioids associated with human overdose. Psychopharmacology (Berl.) (2023).

    Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).