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N-desethyl Protonitazene (hydrochloride)

Item No. 38154

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-2-(5-nitro-2-(4-propoxybenzyl)-1H-benzo[d]imidazol-1-yl)ethan-1-amine, dihydrochloride
Molecular Formula
C21H26N4O3 • 2HCl
Formula Weight
455.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.3 mg/ml
λmax
241 nm
SMILES
CCCOC(C=C1)=CC=C1CC2=NC3=CC([N+]([O-])=O)=CC=C3N2CCNCC.Cl.Cl
InChi Code
InChI=1S/C21H26N4O3.2ClH/c1-3-13-28-18-8-5-16(6-9-18)14-21-23-19-15-17(25(26)27)7-10-20(19)24(21)12-11-22-4-2;;/h5-10,15,22H,3-4,11-14H2,1-2H3;2*1H
InChi Key
FRLXQVPRAVUYKW-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    N-desethyl Protonitazene (hydrochloride) (Item No. 38154) is an analytical reference standard that is structurally similar to known opioids. N-desethyl Protonitazene is a potential metabolite of protonitazene (Item Nos. 29381 | 38143) based on the published metabolism of isotonitazene (Item Nos. 30880 | 27255).1 At the time N-desethyl protonitazene (hydrochloride) (Item No. 38154) was made available for purchase, specific metabolism data had not been published. Contact us if updated information on this molecule is now available. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krotulski, A.J., Papsun, D.M., Kacinko, S.L., et al. Isotonitazene quantitation and metabolite discovery in authentic forensic casework. J. Anal. Toxicol. 44(6), 521-530 (2020).

    Product Citations

    Hardwick, E.K., and Davidson, J.T. Structural characterization of nitazene analogs using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Drug Test Anal. (2025).

    Kozell, L.B., Eshleman, A.J., Wolfrum, K.M., et al. Pharmacology of newly identified nitazene variants reveals structural determinants of affinity, potency, selectivity for mu opioid receptors. Neuropharmacology 276, 110512 (2025).