A flavonoid with diverse biological activities
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Kaempferide

Item No. 29673

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
491-54-3
Synonyms
  • Kaempferol 4'-O-methyl ether
  • NSC 407294
  • 3,5,7-Trihydroxy-4′-methoxyflavone
Molecular Formula
C16H12O6
Formula Weight
300.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:4): 0.2mg/mLEthanol: 3mg/mL
λmax
267, 321, 363 nm
SMILES
OC1=C2C(OC(C3=CC=C(OC)C=C3)=C(O)C2=O)=CC(O)=C1
InChi Code
InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3
InChi Key
SQFSKOYWJBQGKQ-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $134

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    25 mg

    $278

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    50 mg

    $516

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Kaempferide is a flavonoid that has been found in Alpinia and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 97.58 μg/ml).1 Kaempferide is cytotoxic to HT-1080 and Colon 26-L5 cells (EC50s = 2.91 and 5.95 μg/ml, respectively) and decreases lipid accumulation in 3T3-L1 preadipocytes when used at a concentration of 50 μM.2,3 It attenuates decreases in left ventricular systolic pressure (LVSP) and increases in left ventricular end-diastolic pressure (LVEDP) and reduces infarct size in a rat model of myocardial ischemia-reperfusion injury induced by coronary artery ligation when administered at doses of 0.3 and 1 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bian, Q.-Y., Wang, S.-Y., Xu, L.-J., et al. Two new antioxidant diarylheptanoids from the fruits of Alpinia oxyphylla. J. Asian Nat. Prod. Res. 15(10), 1094-1099 (2013).

    2. Banskota, A.H., Tezuka, Y., Prasain, J.K., et al. Chemical constituents of brazilian propolis and their cytotoxic activities. J. Nat. Prod. 61(7), 896-900 (1998).

    3. Kumkarnjana, S., Suttisri, R., Nimmannit, U., et al. Anti-adipogenic effect of flavonoids from Chromolaena odorata leaves in 3T3-L1 adipocytes. J. Integr. Med. 16(6), 427-434 (2018).

    4. Wang, D., Zhang, X., Li, D., et al. Kaempferide protects against myocardial ischemia/reperfusion injury through activation of the PI3K/Akt/GSK-3 β pathway. Mediators Inflamm. 5278218, (2017).