Methylophiopogonanone A

Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities.^1,2,3,4 It increases the uptake of rosuvastatin (Item No. 18813) and atorvastatin (Item No. 10493) in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC₅₀s = 11.33 and 6 µM, respectively).² Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays.¹ In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia.³ It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.⁴

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1. Wang, Y., Liu, F., Liang, Z., et al. Homoisoflavonoids and the Antioxidant Activity of Ophiopogon japonicus Root. Iran J. Pharm. Res. 16(1), 357-365 (2017).

2. Chen, L., Liu, L., Chen, Y., et al. Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis. Xenobiotica 49(10), 1221-1228 (2019).

3. Li, Z., Wu, Y.Y., and Yu, B.X. Methylophiopogonanone A, an Ophiopogon homoisoflavonoid, alleviates high-fat diet-induced hyperlipidemia: Assessment of its potential mechanism. Braz. J. Med. Biol. Res. 53(3), e9201 (2020).

4. He, F., Xu, B.L., Chen, C., et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol. Sin. 37(6), 763-771 (2016).