A metabolite of norcholic acid and derivative of deoxycholic acid
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Nordeoxycholic Acid

Item No. 30837

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β,12α)-3,12-dihydroxy-24-norcholan-23-oic acid
CAS Number
53608-86-9
Synonyms
  • 23-NDCA
  • 23-Nordeoxycholic Acid
Molecular Formula
C23H38O4
Formula Weight
378.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15mg/mLDMF:PBS (pH 7.2) (1:4): 0.2mg/mLDMSO: 10mg/mLEthanol: 10mg/mL
SMILES
C[C@H](CC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
InChi Code
InChI=1S/C23H38O4/c1-13(10-21(26)27)17-6-7-18-16-5-4-14-11-15(24)8-9-22(14,2)19(16)12-20(25)23(17,18)3/h13-20,24-25H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17-,18+,19+,20+,22+,23-/m1/s1
InChi Key
PLRQOCVIINWCFA-AHFDLSHQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    Product Description

    Nordeoxycholic acid is a metabolite of the bile acid norcholic acid and a 23-carbon derivative of deoxycholic acid (Item Nos. 20756 | 18231).1 Levels of nordeoxycholic acid are decreased in the liver of rats in a high-fat diet model of non-alcoholic fatty liver disease (NAFLD) and serum levels are lower in men compared with women.2,3 Nordeoxycholic acid has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakatomi, F., Kihira, K., Kuramoto, T., et al. Intestinal absorption and metabolism of norcholic acid in rats. J. Pharmacobiodyn 8(7), 557-563 (1985).

    2. Tang, Y., Zhang, J., Li, J., et al. Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864(10), 1293-1304 (2019).

    3. Xie, G., Wang, Y., Wang, X., et al. Profiling of serum bile acids in a healthy Chinese population using UPLC-MS/MS. J. Proteome Res. 14(2), 850-859 (2015).

    4. Bergeron, A., Furtado, M., and Garofolo, F. Importance of using highly pure internal standards for successful liquid chromatography/tandem mass spectrometric bioanalytical assays. Rapid Commun. Mass Spectrom. 23(9), 1287-1197 (2009).

    5. Evrard, E., and Janssen, G. Gas-liquid chromatographic determination of human fecal bile acids. J. Lipid Res. 9(2), 226-236 (1968).