A nucleoside form of hypoxanthine
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Isomer(s)
31329Nebularine
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2'-Deoxyinosine

Item No. 31507

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
890-38-0
Molecular Formula
C10H12N4O4
Formula Weight
252.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: slightly soluble
λmax
246 nm
SMILES
O=C1C2=C(NC=N1)N([C@]3([H])O[C@H](CO)[C@@H](O)C3)C=N2O=C1C2=C(NC=N1)N([C@]3([H])O[C@H](CO)[C@@H](O)C3)C=N2
InChi Code
InChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
InChi Key
VGONTNSXDCQUGY-RRKCRQDMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    2’-Deoxyinosine is the nucleoside form of hypoxanthine (Item No. 22254).1 It is a product of DNA damage that is formed from 2’-deoxyadenosine (Item No. 27315) by adenosine deaminase or reactive nitrogen species (RNS).1,2 2’-deoxyinosine (1 mM) enhances apoptosis induced by 5-fluorouracil (5-FU; Item No. 14416) in HT-29 and SW620 cancer cells.3 It also enhances 5-FU-induced tumor growth suppression in an SW620 mouse xenograft model when administered at a dose of 1.6 g/kg twice per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lim, K.S., Jenner, A., and Halliwell, B. Quantitative gas chromatography mass spectrometric analysis of 2'-deoxyinosine in tissue DNA. Nat. Protoc. 1(4), 1995-2002 (2006).

    2. Dong, M., Wang, C., Deen, W.M., et al. Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations. Chem. Res. Toxicol. 16(9), 1044-1055 (2003).

    3. Ciccolini, J., Peillard, L., Evrard, A., et al. Enhanced antitumor activity of 5-fluorouracil in combination with 2'-deoxyinosine in human colorectal cell lines and human colon tumor xenografts. Clin. Cancer Res. 6(4), 1529-1535 (2000).