A β1-adrenergic receptor antagonist
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Levobetaxolol (hydrochloride)

Item No. 33435

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol, monohydrochloride
CAS Number
116209-55-3
Synonyms
  • (S)-Betaxolol
Molecular Formula
C18H29NO3 • HCl
Formula Weight
343.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(C)NC[C@H](O)COC1=CC=C(C=C1)CCOCC2CC2.Cl
InChi Code
InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H/t17-;/m0./s1
InChi Key
CHDPSNLJFOQTRK-LMOVPXPDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $36

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    50 mg

    $68

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    100 mg

    $117

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    250 mg

    $203

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    Product Description

    Levobetaxolol is an isomer of betaxolol (Item No. 18625) and antagonist of the β1-adrenergic receptor (β1-AR; Ki = 0.76 nM for the human receptor).1 It is selective for β1-ARs over β2-ARs (Ki = 32.6 nM), as well as a panel of 89 additional receptors (IC50s = >1 µM). Levobetaxolol inhibits cAMP production induced by isoproterenol (Item No. 15592) in human non-pigmented ciliary epithelial cells (Ki = 16.4 nM). Topical application of levobetaxolol (150 µg/eye) reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension. Formulations containing levobetaxolol have been used in the treatment of glaucoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharif, N.A., Xu, S.X., Crider, J.Y., et al. Levobetaxolol (Betaxon™) and other β-adrenergic antagonists: Preclinical pharmacology, IOP-lowering activity and sites of action in human eyes. J. Ocul. Pharmacol. Ther. 17(4), 305-317 (2001).