An antagonist of GPR35
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ML-145

Item No. 33534

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]-benzoic acid
CAS Number
1164500-72-4
Molecular Formula
C24H22N2O5S2
Formula Weight
482.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/ml, sonicated
SMILES
OC(C=C1NC(CCCN2C(S/C(C2=O)=C\C(C)=C\C3=CC=CC=C3)=S)=O)=C(C=C1)C(O)=O
InChi Code
InChI=1S/C24H22N2O5S2/c1-15(12-16-6-3-2-4-7-16)13-20-22(29)26(24(32)33-20)11-5-8-21(28)25-17-9-10-18(23(30)31)19(27)14-17/h2-4,6-7,9-10,12-14,27H,5,8,11H2,1H3,(H,25,28)(H,30,31)/b15-12+,20-13-
InChi Key
COFMYJWNXSFLKQ-QIROLCGISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

    $167

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    10 mg

    $297

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    Product Description

    ML-145 is an antagonist of G protein-coupled receptor 35 (GPR35).1 It inhibits β-arrestin recruitment induced by the GPR35 agonists zaprinast (Item No. 10010421), cromolyn (Item No. 21379), and pamoic acid (Item No. 13946) in HEK293 cells expressing the human receptor (EC50s = 26, 22, and 8.3 nM, respectively). ML-145 inhibits constitutive and agonist-mediated D-myo-inositol-1-phosphate (IP1) accumulation in cells expressing human, but not rat, GPR35 in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jenkins, L., Harries, N., Lappin, J.E., et al. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J. Pharmacol. Exp. Ther. 343(3), 683-695 (2012).